Reviews

Griffin, BT;Guo, JF;Presas, E;Donovan, MD;Alonso, MJ;O'Driscoll, CM

2016

November

Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs

Validated

1

()

SOLID LIPID NANOPARTICLES IN-VIVO EVALUATION PLGA NANOPARTICLES INSULIN DELIVERY CYCLOSPORINE-A BIODEGRADABLE NANOPARTICLES GASTROINTESTINAL-TRACT THERAPEUTIC PROTEINS MUCOSAL IMMUNIZATION SILICA NANOPARTICLES

The influence of nanoparticle (NP) formulations on the pharmacokinetic, pharmacodynamic and biodistribution profiles of peptide- and protein-like drugs following oral administration is critically reviewed. The possible mechanisms of absorption enhancement and the effects of the physicochemical properties of the NP are examined. The potential advantages and challenges of physiologically-based pharmacokinetic (PBPK) modelling to help predict efficacy in man are discussed. The importance of developing and expanding the regulatory framework to help translate the technology into the clinic and accelerate the availability of oral nanoparticulate formulations is emphasized. In conclusion, opportunities for future work to improve the state of the art of oral nanomedicines are identified. (C) 2016 Elsevier B.V. All rights reserved.

AMSTERDAM

ELSEVIER SCIENCE BV

0169-409X

367

380

10.1016/j.addr.2016.06.006